store-operating calcium channel channels: potential drug targets and biomarkers

Target Name: Store-operating calcium channel channels

NCBI ID: P48901

Other Name(s): SOCs

store-operating calcium channel channels: potential drug targets and biomarkers

Abstract:

Store-operating calcium channel channels (SOCs) are a family of membrane receptors that play a crucial role in various physiological processes, including muscle contractions, neural signaling, and hormone regulation. The discovery of SOCs as potential drug targets has generated significant interest in the development of new therapies for various diseases. In this article, we will review the current research on SOCs, their potential drug targets, and their role as biomarkers for diagnostic purposes.

Introduction:

Calcium channels are a family of transmembrane proteins that regulate the flow of calcium ions into and out of cells. These channels are involved in various physiological processes, including muscle contractions, neural signaling, and hormone regulation. The store-operating calcium channel (SOC) is a specific type of calcium channel that plays a crucial role in the regulation of intracellular calcium levels.

SOCs are characterized by the presence of a unique voltage-dependent 伪-helical structure, which allows them to regulate the flow of calcium ions into and out of cells in a specific direction. This structure is responsible for the ability of SOCs to inhibit the activity of other channels, such as sodium channels, and to modulate the activity of intracellular signaling pathways.

Drug targets:

SOCs have been identified as potential drug targets for various diseases, including hypertension, anxiety disorders, and neurodegenerative diseases.

1.Hypertension:

Hypertension is a common cardiovascular disease that is characterized by an increased blood pressure. Several studies have shown that SOCs are involved in the regulation of blood pressure. For example, research has shown that inhibition of SOCs can lead to relaxation of blood vessels, which can lead to decreased blood pressure.

2. Anxiety disorders:

Anxiety disorders are a common mental disorder that is characterized by feelings of worry, fear, and apprehension. Recent studies have shown that SOCs are involved in the regulation of anxiety-related behaviors. For example, research has shown that inhibition of SOCs can reduce anxiety -like behavior in animals.

3. Neurodegenerative diseases:

Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are characterized by the progressive loss of brain cells. These diseases are associated with the build-up of neurotransmitters, including calcium ions, in the brain. Recent studies have shown that SOCs are involved in the regulation of neurotransmitter release and the maintenance of neuronal excitability.

Biomarkers:

SOCs have also been identified as potential biomarkers for various diseases. For example, research has shown that the level of SOCs is decreased in the brain of individuals with Alzheimer's disease, which could be a potential diagnostic biomarker for this disease. Additionally, research has shown that the level of SOCs is increased in the brain of individuals with depression, which could be a potential diagnostic biomarker for this disease.

Conclusion:

SOCs are a family of membrane receptors that play a crucial role in various physiological processes. The discovery of SOCs as potential drug targets and biomarkers for various diseases has generated significant interest in their study. Further research is needed to fully understand the role of SOCs in disease progression and the development of new therapies.

Protein Name: Store-operating Calcium Channel Channels (nonspecified Subtype)

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